Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains

Committed mast cell progenitors have been postulated to exist in adult mouse and human blood.

We have isolated a rare population of cells in adult mouse blood, committed to the mast cell lineage. Strikingly, the mast cell progenitors from the Th2-prone BALB/c strain expressed FcεRI to a higher degree (66 %) than mast cell progenitors from the Th1-prone C57BL/6 strain (25 %). 

This may imply that mast cell progenitors from allergic patients are more mature than those from normal subjects.

See the published article: Dahlin JS, Heyman B and Hallgren J. Allergy. 2013: DOI: 10.1111/all.12223